References

(in order of presentation)

New uses for old drugs.
Chong CR, Sullivan DJ Jr.
Nature. 2007 Aug 9;448(7154):645-6.

From single genes to gene networks: high-throughput-high-content screening for neurological disease.
Jain S, Heutink P.
Neuron. 2010 Oct 21;68(2):207-17.

A Cell-Based Assay for IκBα Stabilization Using A Two-Color Dual Luciferase-Based Sensor.
R. Eric Davis, Ya-Qin Zhang, Noel Southall, Louis M. Staudt, Christopher P. Austin, James Inglese, Douglas S. Auld.
ASSAY and Drug Development Technologies. February 2007, 5(1): 85-104.

High-content fluorescence-based screening for epigenetic modulators.
Martinez ED, Dull AB, Beutler JA, Hager GL.
Methods Enzymol. 2006;414:21-36.

Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.
Auld DS, Johnson RL, Zhang YQ, Veith H, Jadhav A, Yasgar A, Simeonov A, Zheng W, Martinez ED, Westwick JK, Austin CP, Inglese J.
Methods Enzymol. 2006;414:566-89.

Development of assays for nuclear receptor modulators using fluorescently tagged proteins.
Martinez ED, Hager GL.
Methods Enzymol. 2006;414:37-50.

A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.
Johnson RL, Huang W, Jadhav A, Austin CP, Inglese J, Martinez ED.
Anal Biochem. 2008 Apr 15;375(2):237-48.

Apparent activity in high-throughput screening: origins of compound-dependent assay interference.
Thorne N, Auld DS, Inglese J.
Curr Opin Chem Biol. 2010 Jun;14(3):315-24.

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP.
Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8.

Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility.
Lin Pan, Quynh Ho, Ken Tsutsui and Lori Takahashi
Volume 90, Issue 4, pages 521–529, April 2001

Comparison of nephelometric, UV-spectroscopic, and HPLC methods for high-throughput determination of aqueous drug solubility in microtiter plates.
Hoelke B, Gieringer S, Arlt M, Saal C.
Anal Chem. 2009 Apr 15;81(8):3165-72.

The Toxicologic Assessment of Pharmaceutical and Biotechnology Products.
Dorato, M. A., Vodicnik, M. J.
Principles and Methods of Toxicology. Raven Press, 1994